New York City, January 21, 2026
EliseAI, an innovative AI startup, has signed a substantial 10-year lease for 109,000 square feet in the historic Tiffany & Co. building, showing its commitment to New York City. This move marks a significant expansion as it transitions from its previous office, increasing its footprint in Midtown Manhattan. With a robust workforce and noteworthy growth, EliseAI is reshaping healthcare and housing systems through automation.
EliseAI Expands New York Headquarters in Historic Tiffany Building
Leading AI Startup Reaffirms Commitment to NYC with Major Move
New York City—EliseAI, a groundbreaking AI startup specializing in automating housing and healthcare systems, has just signed a significant 10-year lease for approximately 109,000 square feet at 401 Fifth Avenue. This historic building, once home to Tiffany & Co., marks a major expansion for the company, as they transition from their previous location at 33 East 33rd Street and increase their footprint in Midtown Manhattan by more than 1.5 times.
This bold move reflects not only EliseAI’s rapid growth but also its commitment to the vibrant business landscape of New York City. Since its founding in 2017, the company has made strides in automating workflows for housing providers that span roughly 1 in 6 apartments in the U.S., as well as healthcare providers nationwide. With a workforce exceeding 400 employees and a remarkable recurring revenue growth rate exceeding 100% year-over-year, EliseAI is emerging as one of the most promising tech firms to call New York home.
Historic Significance of the New Location
The choice of the Tiffany & Co. building is not just about space; it’s a statement. Designed by Stanford White of McKim, Mead & White in 1905, this National Historic Landmark boasts an Italian Renaissance façade and a storied presence on Fifth Avenue. EliseAI’s relocation to such an iconic structure signifies not only their expansion but also their longstanding commitment to New York City, a hub for innovation and entrepreneurial spirit.
Funding Details Fueling the Growth
EliseAI’s relocation coincides with its recent $250 million Series E funding round led by prominent investor Andreessen Horowitz in August 2025. This funding round, which values the company at over $2.2 billion, is set to bolster EliseAI’s rapid growth trajectory and further drive product development in the housing and healthcare sectors. The robust backing underscores the belief in the potential of the company and the impact of technology in streamlining crucial systems that affect millions of lives.
Technological Impact on Housing and Healthcare
The solutions offered by EliseAI’s AI agents are transforming the way housing providers and healthcare systems operate. By automating various workflows, the company not only enhances efficiency but also enables providers to focus on delivering better services to their residents and patients. This innovation is vital, especially in a city like New York, where the demand for effective housing solutions and healthcare services is ever-growing.
The Role of Regulation in Business Growth
EliseAI’s expansion highlights the importance of fostering an environment where entrepreneurial innovation can thrive. Fewer regulatory hurdles for tech firms can pave the way for rapid growth, allowing companies like EliseAI to swiftly adapt and cater to the needs of the housing and healthcare markets. This success story exemplifies how strategic investments and a favorable business climate can lead to job creation and robust economic health in New York.
A Bright Future for New York’s Tech Landscape
As New York City continues to reinvent itself post-pandemic, the resilience displayed by companies like EliseAI is a promising sign. Their commitment to growth, combined with significant investments and an innovative approach, sets a strong precedent for small businesses across the region. With the right mix of encouragement from local policymakers and commitment from entrepreneurs, the city’s tech landscape can not only recover but flourish, creating a bright future for all New Yorkers.
Conclusion
EliseAI’s expansion into the historic Tiffany & Co. building is a testament to the company’s growth and the broader potential for tech-driven innovation in New York City. As we witness such remarkable strides in entrepreneurial spirit, it’s crucial for the community to actively engage with and support these local businesses. By fostering a supportive ecosystem and reducing red tape where possible, New York can solidify its status as a leading hub for entrepreneurs and innovative companies.
Frequently Asked Questions
What is EliseAI?
EliseAI is a leading AI startup specializing in automating housing and healthcare systems.
Where is EliseAI relocating to?
EliseAI is relocating to 401 Fifth Avenue, formerly the Tiffany & Co. building, where they have signed a 10-year lease for approximately 109,000 square feet.
What does EliseAI do?
EliseAI develops AI agents that automate workflows for housing providers across approximately 1 in 6 apartments in the U.S. and healthcare providers nationwide.
What are the recent funding details for EliseAI?
EliseAI recently completed a $250 million Series E funding round led by Andreessen Horowitz, valuing the company at over $2.2 billion.
How many employees does EliseAI have?
EliseAI has over 400 employees.
Now Happening on X
- @GlobeStcom (January 21, 2026): EliseAI signs a 109K SF lease at 401 Fifth Avenue for New York headquarters relocation. View on X
- @commobserver (January 20, 2026): EliseAI inks 109K-SF lease at Chetrit Organization’s 401 Fifth Avenue. View on X
- @NYBizJournal (January 20, 2026): EliseAI is moving its NYC headquarters to new Midtown Manhattan offices, quadrupling its footprint. View on X
- @NYBizJournal (January 21, 2026): EliseAI expands to new Midtown offices in NYC, significantly increasing its space. View on X
- @CoyDavidsonCRE (January 21, 2026): The 109,000 SF, 10-year lease at 401 Fifth Avenue signals strong confidence in EliseAI’s growth and future plans, occupying nearly half the building. View on X
- @CoyDavidsonCRE (January 15, 2026): Startup webAI expands at 515 Congress Avenue in Austin, leasing 40K SF after a funding round valuing it at $2.5B, transitioning from startup to anchor tenant. View on X
- @tradedny (January 15, 2026): Deutsche Bank provides loan for 535-545 5th Avenue office/retail property in Manhattan, owned by The Moinian Group. View on X
- @MarketNews_Feed (January 17, 2026): Summit Properties secures court approval for $451M purchase of bankrupt apartments, despite objections from NYC Mayor Zohran Mamdani. View on X
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